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With excess ROS, cells experience oxidative stress , which is at the root of many chronic diseases.[ref] Glutathione can also bind to molecules with the help of detoxification enzymes to eliminate certain types of toxins and heavy metals

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Laser and other light-based therapies are being evaluated as potential therapies in refractory cases, although they carry the risk of worsening the condition in some cases.[] Recently, several systemic agents have been introduced for the treatment of melasma, most often as adjuncts to the established therapeutic modalities

Some amino acids possess antioxidant properties that could theoretically protect against oxidative stress, which contributes to endothelial dysfunction and impaired NO bioavailability

Preclinical efficacy of carfilzomib in BRAF-mutant colorectal cancer models